Open access
Sep 2026
A dedicated motif in human polymerase gamma enables DNA synthesis through replication roadblocks
Mitochondrial DNA (mtDNA) maintenance is essential for cellular homeostasis, and defects in mtDNA replication are linked to a broad spectrum of mitochondrial diseases. During replication, DNA polymerase γ (Polγ) must traverse duplex junctions and stable secondary structures, yet how the human enzyme overcomes these bar...
S. Miguez-Amil, A. Grande-García, Plaza G. A. Ismael et al.
· bioRxiv · 0 citations