Author

A. Girardeau

3 papers indexed here

We haven’t gathered this author’s papers yet. Follow them and we’ll fetch their work.

Not the right person? Other researchers publish under this name.

Open access Oct 2026

The ARumenamide AR-788 suppresses the transient outward current in human iPSC-derived right-ventricular Brugada cardioids

Brugada syndrome (BrS) is an inherited arrhythmia disorder with limited drug therapy, quinidine being the principal agent. Loss-of-function variants in SCN5A reduce the cardiac sodium current (INa), but the arrhythmogenic imbalance also depends on the transient outward potassium current (Ito). Here we generated human i...

Y. Guéret, A. Girardeau, S. Godin et al. · medRxiv · 0 citations

Open access Sep 2026

Selective activation of tetrodotoxin-sensitive sodium channels by AaH-II drives arrhythmogenic late Na+ current in the heart

Abstract Increased late sodium current (INaL) is a central mechanism underlying both inherited and acquired cardiac arrhythmias. Although Nav1.5 is the dominant cardiac sodium channel, multiple tetrodotoxin-sensitive (TTX-S) Nav isoforms are also expressed in cardiomyocytes, particularly within transverse tubules, wher...

Hugo Millet, M. Choteau-Bodor, T. Stervinou et al. · Europace · 0 citations

Open access Jul 2026

Developmental mis-specification of cardiac conduction and structure transcriptome in Brugada syndrome

The findings support a model in which non-SCN5A BrS is associated with early dysregulation of developmental transcriptional networks controlling cardiac conduction and extracellular matrix organization, whereas SCN5A-mediated BrS primarily results from sodium channel deficiency with limited developmental remodeling.

T. Stervinou, B. Cimarosti, R. Canac et al. · medRxiv · 0 citations