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Author

A. Gilly

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Review Open access Sep 2026

Causal relationship between liver fat reduction and clinical outcomes in human genetic studies and randomized clinical trials of metabolic-dysfunction associated steatohepatitis

Reliance on invasive liver biopsy endpoints is a major limiting factor in new therapeutic development for metabolic dysfunction-associated steatohepatitis (MASH). While liver fat accumulation is considered a driver of early disease, liver fat reduction is not recognized as a surrogate endpoint by health authorities. He...

N. Verweij, G. Hindy, Q. Nguyen et al. · 0 citations
Open access Aug 2026

FNIP1 variants are associated with favourable metabolism in 1 million humans

An exome-sequencing analysis of 1,032,116 people from America, Europe and Asia is performed, and associations between rare protein-coding variants and the ratio of triglyceride to high-density-lipoprotein cholesterol (TG:HDL) are estimated.

G. Hindy, Rene C. Adam, O. Sosina et al. · 2 citations

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