A sphingomyelin-cholesterol complex regulates TLR4 activation in microglia
Microglial activation in response to lipopolysaccharide (LPS) requires Toll-like receptor 4 (TLR4) redistribution into cholesterol- and sphingolipid-rich membrane domains, yet the lipid determinants of this process remain unclear. Here, we identify cholesterol accessibility as a key driver of TLR4-dependent microglial...