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Open access Sep 2026

Mutations in the macrodomain 1 of nsp3 attenuate PEDV virulence in vivo without impairing in vitro replication

ABSTRACT The conserved macrodomain 1 (Mac1) within coronavirus nsp3 reverses ADP-ribosylation of proteins and contributes to viral virulence. While Mac1 has been characterized in several coronaviruses, its role in porcine epidemic diarrhea virus (PEDV) remains unknown. Since D445 and N462 are functionally important res...

Ming-De Liu, Men Thi Hoai Duong, Thamonpan Laocharoensuk et al. · 0 citations
Review Open access Sep 2026

SARS-CoV-2 Drug-Resistant Mutations in Non-Structural Proteins

Various antiviral drug therapies have been developed for the treatment of coronaviruses, particularly SARS-CoV-2. However, the emergence of drug-resistant mutations is detrimental to clinical efficacy and global public health. Antiviral usage exerts selective pressures on viruses that manufacture an environment for res...

Madison Shaw, A. Fehr · 0 citations

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