Author

A. Dighe

3 papers indexed here

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Open access Sep 2026

70 Lymphocyte Hsp70 is a Novel Predictive Biomarker for Response to Immune Checkpoint Inhibitors in Metastatic Renal Cell Carcinoma

A scRNA-seq atlas of tumors from metastatic RCC found a novel factor, Hsp70, that in lymphocytes strongly predicts response and greatly extended PFS after ICI, indicating that Hsp70 expression in lymphocytes predicts response to ICI across timepoints and cohorts.

Ethan C. Burns, S. Kashima, Rishabh Rout et al. · The Oncologist · 0 citations

Open access Sep 2026

56 Identification and Prioritization of Human Endogenous Retrovirus–Derived Antigens for mRNA Vaccine Development in Renal Cell Carcinoma

Abstract Background Immune checkpoint inhibitors improve outcomes in clear cell renal cell carcinoma (ccRCC), yet most patients do not achieve durable responses due in part to insufficient tumor antigenicity. While neoantigen vaccines have shown promising early-phase results in ccRCC, their patient-specific design limi...

F. Scallo, A. Dighe, Josephine Burdekin et al. · The Oncologist · 0 citations

Open access Sep 2026

8 Single Cell Transcriptomic Investigation of Renal Cell Carcinoma (RCC) Reveals Tissue Resident Memory Exhausted CD8+ T Cell Signature Associated with Resistance to Immune Checkpoint Inhibition (ICI)

A tissue residency gene program in Tex cells associated with non-response to immunotherapy was identified and nominates resident memory exhausted CD8+ T cells as a targetable subset of cells to improve CD8+ T cell-mediated anti-tumor immunity.

Rishabh Rout, S. Kashima, M. Hugaboom et al. · The Oncologist · 0 citations