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Author

A. den Braber

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Open access Oct 2026

Alzheimer's disease genetics converges on microglial and neuronal dysregulation.

Alzheimer's disease (AD) is the most common cause of dementia, with global case numbers projected to reach 153 million in 20501. AD is highly heritable, with twin-based heritability estimates of 60-80%2. Although 1,200 causal loci are predicted to exist for AD3, approximately 80 loci have been associated with AD in two...

E. Uffelmann, D. Wightman, S. Bahrami et al. · 0 citations
Open access Sep 2026

CSF proteomic quantitative trait loci mapping reveals genetic insights into Alzheimer’s disease

Many AD pQTLs in CSF were enriched in neuroimmune activation, suggesting a genetic basis for neuroimmune dysregulation in AD, and how genetic variation shapes protein expression in the central nervous system is highlighted.

L. Reus, Chen-Yang Jiang, N. Vilor-Tejedor et al. · 0 citations
Open access Aug 2026

AMYPAD-PNHS: A Pan-European, Multi-Site & Multimodal MRI Dataset of Older Adults Without Dementia

The Amyloid Imaging to Prevent Alzheimer’s Disease Prognostic and Natural History Study (AMYPAD-PNHS) multimodal magnetic resonance imaging (MRI) dataset provides open-access longitudinal MRI data of 2759 cognitively normal or mild cognitive impairment individuals to enhance generalizability and comparability between f...

L. Pieperhoff, M. Tranfa, Prithvi Arunachalam et al. · 0 citations

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