Author

A. Dehghan

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Open access Sep 2026

A novel framework leveraging non-causal associations reveals shared pathways linking inflammation and cancer risk

This work proposes a framework for identifying confounders of two non-causally related traits by employing cross-trait pleiotropy analysis to detect genetic loci that affect both traits and multi-trait colocalisation to identify molecular phenotypes mediating these effects.

J. Yarmolinsky, F. Cavallo, F. Koskeridis et al. · medRxiv · 0 citations

Open access Jul 2026

Identifying protein biomarkers and therapeutic targets in psoriasis through integrative genomic, proteomic and transcriptomic analysis

Plasma proteins are promising biomarkers and potential drug targets in psoriasis. We conducted a two-sample Mendelian randomisation analysis integrating protein quantitative trait loci from UK Biobank and deCODE genetics with a psoriasis GWAS meta-analysis of 36,466 cases. To strengthen causal inference, we performed c...

D. Meena, C. V. Chalitsios, J. Huang et al. · medRxiv · 0 citations

Open access Jul 2026

Exploring molecular signatures of exposure to water disinfection by-products: A multi-omic analysis across multiple exposure routes.

BACKGROUND Disinfection by-products, including those arising from secondary reactions between chlorinated reagents and natural organic matter such as trihalomethanes (THMs), have been associated with several adverse health outcomes, such as bladder and colorectal cancer. AIMS We aim to identify metabolic signatures o...

Sibo Lucas Cheng, P. Keski-Rahkonen, A. C. Chatziioannou et al. · Environment International · 0 citations