Abstract Background Treatment-resistant schizophrenia (TRS), affecting roughly one-third of patients, shows poor response to standard antipsychotics and may reflect more severe or distinct neurophysiological disruptions compared to treatment-responsive cases. Prior evidence from imaging and other methods suggested cort...
A. Barone, G. Senerchia, G. De Simone et al.· International Journal of Neu...· 0 citations
Abstract Background About a third of schizophrenia patients are refractory to antipsychotics, a condition characterized by poor clinical and functional outcomes known as treatment-resistant schizophrenia (TRS). The disorganization domain may represent the leading factor in categorizing a schizophrenia patient as affect...
M. Ciccarelli, F. Iasevoli, A. Barone et al.· International Journal of Neu...· 0 citations
Dyslipidemia and inflammation are two hallmarks of schizophrenia (SCZ), but the link between these two conditions remains elusive. We studied 40 SCZ patients and 40 age- and sex-matched healthy controls (CTRL) analyzing serum total, low-density lipoprotein (LDL), and high-density lipoprotein (HDL) cholesterol. In addit...
S. Bagnasco, G. De Simone, G. Cernera et al.· International Journal of Mol...· 0 citations
Abstract Background Formal thought disorders (FTDs) are a fundamental component of the psychopathology of schizophrenia (SCZ), characterized by fragmented conceptual organization and loss of associative coherence [1]. FTDs are more frequent and severe in individuals with treatment-resistant schizophrenia (TRS), who sho...
F. Iannotta, L De Santis, A. Catino et al.· International Journal of Neu...· 0 citations
Abstract Background Schizophrenia pathophysiology has consistently been associated with disruptions in the glutamatergic pathway, postsynaptic density (PSD) proteins, and monoaminergic neurotransmission, especially the dopaminergic one. Proper functionality of each neurotransmitter system is crucial for brain health, b...
G. De Simone, T. Nuzzo, A. di Maio et al.· International Journal of Neu...· 0 citations
Abstract Background Treatment-resistant schizophrenia (TRS), defined as the persistence of symptoms despite adequate antipsychotic treatment, remains frequently underrecognized, with clozapine, the gold standard, introduced only after an average delay of 4–9 years. In this study, we aimed to identify which Positive and...
L. Vellucci, P. Mirra, A. Nasti et al.· International Journal of Neu...· 0 citations
BACKGROUND
The Fusiform Gyrus (FG), a brain region relevant for the interaction between cognitive processes and emotional behavior, especially emotion recognition and interpretation of social cues, has been linked to the pathophysiology of schizophrenia conceptualized as a disorder of aberrant synaptic function and bra...
M. Ciccarelli, B. Mazza, A. Nasti et al.· Neuroscience and Biobehavior...· 0 citations
Abstract Background Recent evidence supports the hypothesis that schizophrenia is part of a continuum of neurodevelopmental disorders (NDDs), characterized by early alterations in fronto-striatal, parietal, and cerebellar circuits (Owen, 2017). In this perspective, Autism Spectrum Disorder Level 1 (ASD-L1) and schizoph...
C. Ceparano, F. Iannotta, C. Ricci et al.· International Journal of Neu...· 0 citations
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