Author

A. D'Andrea

3 papers indexed here

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Sep 2026

Abstract A127: Targeting replication stress in pancreatic cancer: results of a phase 1b trial of azenosertib and gemcitabine in second line pancreatic cancer after progression on FOLFIRINOX

Treatment options for patients with pancreatic ductal adenocarcinoma (PDAC) who have had progressive disease on FOLFIRINOX (oxaliplatin, irinotecan, leucovorin, and infusional 5-fluorouracil) are limited, and patients are typically treated with gemcitabine and nab-paclitaxel. Targeting therapeutic vulnerabilities...

B. Huffman, Haeseong Park, Nadine A. Jackson et al. · Cancer Research · 0 citations

Open access Aug 2026

A Phase II Study of Berzosertib in Combination with Carboplatin Compared with Docetaxel with Carboplatin in Metastatic Castration-Resistant Prostate Cancer

The combination of the ATR inhibitor berzosertib with carboplatin demonstrated a lower ORR and more frequent ≥ grade 3 TrAEs compared with docetaxel + carboplatin in this heavily pretreated, biomarker-unselected mCRPC population.

A. Choudhury, C. Zhong, Wan-Ling Xie et al. · Cancer Research Communicatio... · 0 citations

Open access Sep 2026

The role of CHAMP1 in chromatin-mediated DNA damage repair.

Defects in the replication stress response are major drivers of cancer development and present key targetable vulnerabilities that can be exploited for anti-cancer therapy. Recent studies have identified CHAMP1 as a novel DNA damage repair factor with roles in double-strand break repair and the replication stress respo...

Felix Y. Zhou, Jinal A. Patel, Aindri H. Patra et al. · DNA Repair · 0 citations