Author

A. D. de Smith

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Open access Aug 2026

A functional genomics screen of human B-cell differentiation reveals convergent mechanisms of inherited childhood leukemia predisposition

B-cell acute lymphoblastic leukemia (B-ALL) is the most common childhood cancer, yet the mechanisms by which inherited risk variants predispose to leukemia development remain poorly understood. A major challenge to studying these mechanisms has been the lack of model systems that faithfully capture the transient develo...

Lara Wahlster, Anna-Lena Neehus, Andrew J. Lee et al. · bioRxiv · 0 citations

Review Open access Aug 2026

The Childhood Cancer and Leukemia International Consortium (CLIC): Expanding Global Collaboration in Pediatric Cancer Etiology Research

The integration of genetic ancestry and germline susceptibility data is clarifying ancestry-related differences in leukemia biology and outcomes, while confirming risk loci with population-specific effects.

Ana M. Mora, J. Mejía-Aranguré, J. Dockerty et al. · Cancer Epidemiology · 0 citations