Open access
Sep 2026
Persistent IL-18 fuels expansion of CD38+HLA-DR+CD8+ T cells in Still's disease and macrophage activation syndrome.
OBJECTIVE Still's disease (SD) is an autoinflammatory disorder characterized by remarkably high IL-18 levels. Increasing evidence suggests that adaptive immunity also contributes to its pathogenesis, particularly in refractory courses. Macrophage activation syndrome (MAS), one of SD's most severe complications, is asso...
Greta Rogani, R. Erkens, A. Bodelón et al.
· Arthritis & Rheumatology · 0 citations