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A. Croft

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Open access Sep 2026

CD248/Endosialin regulates synovial fibroblast state to control coupling of inflammation and bone damage in murine models of immune-mediated inflammatory arthritis and ageing.

OBJECTIVE Synovial fibroblasts directly contribute to inflammation and damage in immune-mediated inflammatory arthritis. CD248/Endosialin is expressed by fibroblasts in the synovium, is highly upregulated during inflammation and has been proposed as a potential therapeutic target. This study aimed to map the expression...

Samuel Kemble, C. Wehmeyer, James M. Brown et al. · 0 citations
Open access Aug 2026

Synovial lining macrophages form during early postnatal life via fetal-derived CX3CR1+ cells and AQP1+ intermediates.

The synovial lining maintains joint integrity, produces lubricating fluid, and forms a sterile barrier disrupted in inflammatory joint disease. It consists of specialized fibroblasts and macrophages, but its developmental timing and mechanisms are not well understood. We used genetic mouse models, imaging, and single-c...

Marlene S. Magalhaes, B. Malengier-Devlies, Guillaume Seuzaret et al. · 0 citations

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