Review
Open access
Oct 2026
The ternary complex structure as a foundation for structure-guided molecular glue design.
Molecular glues are opening up new therapeutic areas by turning previously undruggable and intractable proteins into tractable targets through the formation or stabilisation of a ternary complex between two proteins. The present review focuses on how such structures are obtained and leveraged to guide rational design....
A. Cowan
· Essays in Biochemistry · 0 citations