The deubiquitinase USP4 stabilizes the SCFFBXO24 ubiquitin E3 ligase to regulate immunity in experimental pneumonia
The ubiquitin E3 ligase SCFFBXO24 targets key proteins for degradation that regulate important biological processes, but the mechanisms controlling cellular concentrations of its receptor subunit, F-box only protein 24 (FBXO24), remain unknown. Here, Haemophilus influenzae type B (HiB), an important cause of pneumonia,...