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Open access Sep 2026

EPIC: An open community challenge for sequence-based prediction of transcription initiation in five non-model metazoans

Predicting gene expression from DNA sequence is a central problem with critical biological and clinical implications. Recent sequence-to-function models are reported to achieve improved performance, yet it remains unclear how much of what they learn reflects genuine principles of eukaryotic transcription initiation and...

Ilya E. Vorontsov, Nikita Gryzunov, Bayley R. McDonald et al. · 0 citations
Aug 2026

The transcription factor CLAMP is required for neurogenesis in Drosophila melanogaster.

It is suggested that CLAMP regulates a core transcriptional program which drives NSC proliferation and differentiation via cell-intrinsic and niche-dependent mechanisms involving niche glia and transcriptional regulation of Notch and Tailless.

Maria A. Tsiarli, James A. Kentro, A. Conard et al. · 0 citations

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