Author

A. Cherubini

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Open access Sep 2026

Age-related reduction in D-dimer cut-off specificity: Diagnostic relevance in geriatric patients.

INTRODUCTION D-dimer testing is widely used to exclude pulmonary embolism (PE), but its specificity declines sharply with age. Evidence in very old adults is limited, as most validation studies include few patients aged ≥80 years. This study aimed to identify and validate a clinically appropriate D-dimer threshold for...

F. Marchegiani, R. Galeazzi, L. Antognoli et al. · Thrombosis Research · 0 citations

Open access Aug 2026

Multimorbidity patterns influence mobility disability prevention in frail older adults from the SPRINTT trial

Preserving independence in older adults is a public health priority. Lifestyle interventions can prevent physical disability, but whether their efficacy is influenced by multimorbidity profiles is unclear. In this post hoc analysis of the SPRINTT randomized trial (NCT02582138), we investigated whether the efficacy of a...

D. L. Vetrano, Caterina Gregorio, F. Triolo et al. · Nature Aging · 0 citations