Sep 2026
Senescence-directed nanotherapy ameliorates fibrosis and overcomes immune exclusion in cancer.
Fibrotic remodeling of tissues and tumors establishes immunosuppressive microenvironments that drive organ dysfunction and, in cancer, limit response to immunotherapy. Senescent-like cells are conserved drivers of fibrosis and therapeutic targets, yet their functional heterogeneity complicates therapeutic intervention....
Clemens Hinterleitner, Valentin J. A. Barthet, Hailey V. Goldberg et al.
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