Author

A. Chandio

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Open access 2026

Physicochemical Characterization, Microencapsulation, and In-vitro Wound Healing Potential of Cold-Pressed Industrial Hemp Seed Oil.

Cold-pressed industrial hemp seed oil (CPCSSO) with a fully characterized physicochemical profile; including fatty acids, sterols and quality indices is a natural regenerative agent due to its high content of essential fatty acids (EFA) and its dominant beta-sitosterol fraction (62.10 %). However, its susceptibility to oxidation (Iodine Value: 157) limits its effectiveness when applied topically. To address this issue, this study is aimed to stabilize CPCSSO through an innovative complex coacervation system using a gelatin/gum Arabic matrix crosslinked with natural transglutaminase (Tgase) and tannic acid (TA). Physicochemical analyses confirmed that CPCSSO retained excellent quality criteria, including low free fatty acid and peroxide values. In vitro biological tests showed that unencapsulated CPCSSO at concentrations as low as 0.12 mg/mL significantly accelerated wound healing achieving highly statistically significant results (48 hours) and increased proliferation of normal human dermal fibroblast cells by 72 %. This demonstrates the oil's substantial potential for skin regeneration, although microencapsulation improved the stability of CPCSSO, the biological activity of the encapsulated CPCSSO decreased. The current findings highlight the effectiveness of CPCSSO in wound healing and suggest that further optimization is necessary for the TGase-TA crosslinking system to serve as a reliable method for the topical delivery of natural bioactive compounds.

E. Duman, A. Evcin, Sabire Duman et al. · Journal of Oleo Science · 0 citations

Jul 2026

Fabrication and physicochemical characterization of sodium alginate-based hydrogel incorporated with aloe vera and chitosan for wound dressing applications

Hydrogels are considered as promising polymeric biomaterials for wound dressing due to the desirable properties of wound healing. In this work, the use of natural polymeric biomaterials such as aloe vera (AV), chitosan (CH) in sodium alginate (SA)-based hydrogels, a novel hydrogel was produced and characterized that might be applied to healing wounds. Initially, a neat SA specimen was used as a control. Afterward, the specimens were fabricated via the solvent casting method with varying amounts of CH and AV. Morphological changes were observed in SA after the introduction of AV and CH using X-ray diffraction (XRD). The loss of crystalline nature in the SA–Neat and SA–AV samples were observed after the incorporation of CH was revealed by the loss of peaks that were previously observed in the SA–Neat and SA–AV samples. Fourier transform infrared (FTIR) spectroscopy demonstrated strong bonding between SA and the incorporated materials. The samples containing CH exhibited comparatively higher degradation, whereas the AV samples degraded slowly. The hardness of the tested samples increased with the incorporation of AV, whereas an increase in hardness was observed with the incorporation of CH. Thermogravimetric analysis (TGA) and differential scanning calorimetry (DSC) revealed an increase in thermal stability in samples containing AV followed by samples containing CH.

Romaisa Iqbal, E. H. Mirza, S. F. Jawed et al. · Journal of bioactive and com... · 0 citations