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A. C. L. Leite

2 papers indexed here

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Open access Sep 2026

Highly Selective Thiazole Derivatives as Promising Anti- Toxoplasma gondii Agents

Toxoplasmosis, caused by the protozoan Toxoplasma gondii, remains a significant global health challenge, particularly for immunocompromised individuals. Current therapies, based on pyrimethamine and sulfadiazine, are limited by toxicity, suboptimal efficacy, and the emergence of resistant parasite strains, highlighti...

Ingrid de Oliveira Dias, Gabriel Cândido Moura, Lucas Manoel da Silva Sousa et al. · 0 citations
Open access Aug 2026

Pyridyl‐Thiazole‐Thiosemicarbazones as Antitrypanosomatidae Agents: Design, Synthesis, and In Silico Profiling

Chagas disease and leishmaniasis are neglected tropical diseases caused by the trypanosomatid protozoa Trypanosoma cruzi and Leishmania spp., respectively. Currently available treatments are often insufficiently effective and lack the characteristics of ideal therapeutics. Here we report the design, synthesis, and anti...

Anderson José Firmino Santos da Silva, Daiane Santiago da Cruz Olimpio, Lucas Manoel da Silva Sousa et al. · 0 citations

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