Open access
Oct 2026
Microbiota-host genetic interactions modulate MASLD risk in PNPLA3I148M carriers via ceramides and are reversible by targeted microbial interventions.
BACKGROUND The factors that determine when genetic susceptibility to metabolic dysfunction-associated steatotic liver disease (MASLD) progresses to clinically significant liver injury remain incompletely understood. OBJECTIVE We investigated whether disruption of the intestinal host-microbiota interface acts as a con...
Madhuri Haque, T. Lesker, U. Rolle-Kampczyk et al.
· Gut · 0 citations