Autoimmune and autoinflammatory disorders can exhibit significant clinical and immunological overlap, often leading to diagnostic delays and therapeutic misdirection. Polyclonal hypergammaglobulinemia and antinuclear antibodies (ANA), although classically associated with autoimmune processes, have been occasionally rep...
Ghalia Khellaf, A. Benziane· International Journal of Adv...· 0 citations
Background/Objectives: Multicentric Castleman disease (MCD) is a rare systemic lymphoproliferative disorder driven by interleukin-6 (IL-6) dysregulation and frequently associated with human herpesvirus 8 (HHV-8) infection. AA amyloidosis is a severe complication of chronic inflammatory states, resulting from extracellu...
Ghalia Khellaf, Zoheir Benzekri, Djenatte Hakem et al.· International Journal of Adv...· 0 citations
We report the long-term follow-up of an Algerian family from the south of the country with TNF Receptor Associated Periodic Syndrome (TRAPS) associated with AA amyloidosis, carrying the heterozygous p.Thr79Met mutation in the TNFRSF1A gene. The proband, a 36-year-old woman, and her affected father (I/2) both died from...
Ghalia Khallaf, A. Benziane, T. Rayane et al.· International Journal of Adv...· 0 citations
Background: Neurofibromatosis Type 1 (NF1) is an autosomal dominant neurocutaneous disorder. Renal complications include renovascular hypertension. We report a case diagnosed in a nephrology setting after a 14 year delay.
Case presentation: A 27 year old woman with severe hypertension, acute myeloid leukemia (treated w...
Ghalia Khellaf, H. Sahel, A. Benziane· International Journal of Adv...· 0 citations
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