Author

A. B. Mahardhika

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Open access Oct 2026

Molecular insights into GPR55 modulation reveal an atypical activation mechanism and glycosylation-dependent efficacy regulation

GPR55 is a lipid-activated G protein-coupled receptor (GPCR) implicated in metabolism, inflammation, and neurodegeneration. Lysophosphatidylinositol (LPI) species are proposed as endogenous agonists, but progress in understanding GPR55 function has still been limited by suboptimal chemical probes. Here, we present cryo...

T. Claff, Chamalee Demalgiriya-Gamage, A. B. Mahardhika et al. · Nature Communications · 0 citations

Open access Sep 2026

Mechanism of GPR84 allosteric modulation at a helix 8–proximate site

Allosteric modulators offer opportunities for pathway-selective G protein–coupled receptor (GPCR) signaling, but the mechanisms enabling biased allosteric modulation remain poorly understood. We identify a helix 8–proximate allosteric site in the immune-metabolic receptor GPR84 and define how it achieves Gi-biased sign...

Xuan Zhang, Abdul-Akim Guseinov, Laura Jenkins et al. · Science Advances · 0 citations