Open access
Jul 2026
Social regression stems from a latent phase of GABAergic dysfunction and sensory breakdown in a model of synaptopathy.
Boosting tonic inhibition from birth with chronic treatment with the GABAA receptor agonist gaboxadol fully reversed social deficits, restored the integrity of vocal circuits, and the multimodal integration of sensory inputs.
Lorenzo Ciano, Sebastian Sulis Sato, F. Galluzzi et al.
· Molecular Psychiatry · 0 citations