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Author

A. Armirotti

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Open access Sep 2026

Controlled Blood-Brain Barrier Modulation by a High-Affinity Claudin-5 Peptide Binder

The blood-brain barrier (BBB) is a specialized interface that tightly regulates the exchange of molecules between the bloodstream and the brain. Its barrier function relies on a monolayer of brain endothelial cells sealed by tight junctions (TJs) that restrict paracellular flux through claudin-5 (CLDN5) multimeric comp...

Alessandro Berselli, Martina Trevisani, Giulio Alberini et al. · 0 citations
Open access Jul 2026

Social regression stems from a latent phase of GABAergic dysfunction and sensory breakdown in a model of synaptopathy.

Boosting tonic inhibition from birth with chronic treatment with the GABAA receptor agonist gaboxadol fully reversed social deficits, restored the integrity of vocal circuits, and the multimodal integration of sensory inputs.

Lorenzo Ciano, Sebastian Sulis Sato, F. Galluzzi et al. · 0 citations

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