Abdullah M. Alharran

Comparative Efficacy and Safety of Needling-Based Therapies Versus Ablative Fractional Lasers for Scar Management: A Systematic Review and an Exploratory Meta-Analysis.

BACKGROUND Needling-based therapies and ablative fractional lasers are widely used for scar management, but their efficacy and safety remain uncertain. In this systematic review, we aimed to assess the safety and efficacy of both needling-based therapy and ablative fractional laser therapy. METHODS This review follow...

Toxic Metal-Essential Trace Element Imbalance in Cardiometabolic Disease: Ferroptosis as a Mechanistic Link Between Environmental Exposure and Vascular Injury

Efficacy and safety of digoxin/furosemide for cutaneous warts: a systematic review and meta-analysis of eight randomized controlled trials

Background: Cutaneous warts, caused by human papillomavirus, are common and often resistant to standard treatments, such as cryotherapy, which have high recurrence rates and side effects. Ionic contra-viral therapy (ICVT), combining digoxin and furosemide, has emerged as a novel therapeutic approach, but its clinical e...

Melatonin Supplementation in the Management of Irritable Bowel Syndrome: An Updated Systematic Review and Meta-Analysis.

BACKGROUND Irritable bowel syndrome (IBS) is a common disorder of gut-brain interaction characterized by recurrent abdominal pain and altered bowel habits, with substantial effects on quality of life and healthcare utilization. Melatonin has been proposed as a potential adjunctive therapy because of its effects on visc...

Self-Fitting Versus Professional-Fitting Hearing Aids: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Self-fitting hearing aids showed no clear differences from professional best-practice fitting across several patient-reported and functional outcomes in adults with uncomplicated mild-to-moderate hearing loss, and it is suggested that well-designed self-fitting pathways may have potential as an accessible alternative f...

Efficacy and Safety of Baxdrostat for Patients With Uncontrolled or Resistant Hypertension: A Systematic Review and Meta-Analysis.

Baxdrostat lowers blood pressure and aldosterone levels in uncontrolled and resistant hypertension but increases potassium and modestly reduces eGFR, supporting careful laboratory monitoring and longer trials to evaluate long-term clinical outcomes.