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Author

A. Alaa

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5 papers indexed here

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Open access Oct 2026

Engineering next-generation CAR-NK cells for hematological malignancies: genome editing, synthetic biology, and precision immunotherapy

Chimeric antigen receptor (CAR)-based immunotherapy has transformed cancer treatment by enabling engineered immune cells to selectively recognize and eliminate malignant targets, with CAR-T cells establishing the first major clinical success in this field. However, severe associated toxicities, logistical complexitie...

A. Bahr, Youssef Basem, Amani Alhejely et al. · 0 citations
Review Oct 2026

Rewiring the Tumor-Immune Ecosystem: Extracellular Vesicles in the Next Era of Cancer Immunotherapy.

Cancer immunotherapy has transformed oncology by enabling immune-mediated tumor elimination; however, durable responses remain limited, particularly in solid tumors due to antigen heterogeneity, immunosuppressive tumor microenvironment, and adaptive resistance mechanisms. To overcome these barriers, therapeutic paradig...

A. Bahr, Youssef Basem, A. Alaa et al. · 0 citations
Review Open access Aug 2026

Green-Synthesized Nanomaterials for Fenton and Fenton-like Degradation of Pharmaceutical Pollutants in Water Treatment

Pharmaceutical pollutants have emerged as a critical class of aquatic micropollutants due to their continuous release, persistence, and potential impacts on ecosystems and human health. Conventional wastewater treatment systems are often insufficient to achieve complete removal, necessitating the development of advance...

Ghazala Muteeb, Youssef Basem, A. Alaa et al. · 0 citations
Review Open access Sep 2026

Nanozyme-Based Therapeutic Strategies in Atherosclerosis: Mechanistic Insights, Targeting Approaches and Translational Challenges.

Atherosclerosis is a gradual process that occurs on the artery walls caused by multiple drivers, such as the presence of oxidative stress, chronic inflammation and disorganized lipid metabolism resulting in increased plaque formation and life-threatening cardiovascular disease. Due to their poor bioavailability, rapid...

Ghazala Muteeb, Youssef Basem, A. Alaa et al. · 0 citations
Review Open access Sep 2026

Epigenetic Plasticity in Triple-Negative Breast Cancer: Mechanisms of Therapy Resistance, Biomarkers, and Therapeutic Vulnerabilities

Overall, epigenetic plasticity represents both a major driver of TNBC resistance and a therapeutically exploitable vulnerability, provided those future strategies account for tumor heterogeneity, adaptive cell-state transitions, biomarker-guided patient selection, and combination-based treatment design.

A. Alaa, Salma A. B. El-Din, Mohannad A. Farrag et al. · 0 citations

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