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Author

A. Al Tuwaijri

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5 papers indexed here

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Open access Oct 2026

Structure-based discovery of a novel Granzyme A (GZMA) inhibitor for autism spectrum disorder through integrative transcriptomics, virtual screening, and long-timescale molecular dynamics simulations

Granzyme A (GZMA) is a trypsin-like serine protease expressed in cytotoxic lymphocytes that cleaves gasdermin B (GSDMB) to release a pore-forming N-terminal fragment, thereby inducing pyroptosis, a lytic and pro-inflammatory form of programmed cell death. This pathway has been implicated in immune dysregulation reporte...

M. Alharbi, Abdulrahman Alshammari, O. Al-shabanah et al. · 0 citations
Open access Oct 2026

Inhibition of Monoacylglycerol Lipase Suppresses Lipopolysaccharide-Enhanced Melanoma Proliferation and Migration

Background/Objectives: Lipid metabolism dysregulation contributes to cancer progression. Monoacylglycerol lipase (MAGL) breaks down 2-arachidonoylglycerol (2-AG) into glycerol and arachidonic acid, a substrate for cyclooxygenase-2 (COX-2) to produce pro-inflammatory mediators such as prostaglandin E2 (PGE2). Lipopolysa...

Faris Almutairi, Yazeed Alneef, H. Albassam et al. · 0 citations
Open access Sep 2026

Low Molecular Weight Dextran Sulfate Mitigates Acute Kidney Injury Induced by Renal Ischemia/Reperfusion: Implication of JNK/p38 MAPK and Caspase-3

Low molecular weight-dextran sulphate exerts nephroprotective effects against RI/RI by restoring redox balance, suppressing inflammatory signaling, JNK/p38 MAPK, and caspase-3, highlighting its potential as a therapeutic strategy for renal I/R-induced AKI.

Nadrah S. Alamri, Ahlam M. Alhusaini, W. Sarawi et al. · 0 citations
Open access Sep 2026

Impact of Cannabidiol and Its Synthetic Derivative on Fentanyl Consumption and Fentanyl-Induced Neurometabolic Alterations in Mice

These studies provide evidence about the in vivo behavioral and neurometabolic profiles of fentanyl after pretreatment with CBD and synthetic CBD, presenting them as possible pharmacological tools for OUD research.

Dalal A. Alkhelb, Jomana M. Alahmadi, Maisa S. Alqarni et al. · 0 citations
Open access Jul 2026

Involvement of NOD1/NF-κB/MAPK pathway in the protective effect of procyanidin B2 against methotrexate-induced nephrotoxicity

PCB2 reduced oxidative stress and inflammatory responses, indicating potential protective effects against MTX-induced kidney damage and prevented tissue injury and restored the altered parameters.

A. Al Tuwaijri, Ahlam M. Alhusaini, W. Sarawi et al. · 0 citations

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