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Preprint Oct 2026

Comparing local and global optimization reveals untapped hybrid potentials for machine learning-based inverse planning

Machine learning (ML) models for normal tissue complication probability (NTCP) can be embedded directly into inverse treatment planning, but the resulting optimization problems are generally nonconvex, and the choice between global and local optimization involves a trade-off between optimality guarantees and computatio...

T. Ortkamp, Florian Leininger, Zhong-Xing Liao et al. · 0 citations
Oct 2026

Escalation of Resting Heart Rate and Tachycardia as a Response to Thoracic Radiotherapy: Implications for Cardiovascular Outcomes after Radiotherapy.

BACKGROUND Cardiac toxicity is a well-recognized, but poorly understood complication of radiotherapy (RT). In non-oncological settings, there is an established relationship between resting heart rate and cardiovascular health. OBJECTIVES To study the incidence and pattern of resting heart rate (rHR) as an early sign...

A. Ajdari, M. Bobić, C. Ciausu et al. · 0 citations

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