Benchmarking Statistical Methods for Environmental Chemical Mixtures: Prediction, Interaction Detection, and an Applied Analysis of Metals, Essential Elements and Diabetes
Background. Human populations are exposed to complex chemical mixtures, making interaction detection a central challenge in environmental epidemiology. We benchmarked methods for prediction and recovery of interaction structure. Methods. Eight approaches—main-effects Lasso (glmnet_main), interaction Lasso (glmnet_int),...