A. Adameová

Mitochondrial DNA in necrosis-like cell death in failing hearts: evidence and mechanisms fostering damage.

Mitochondrial DNA (mtDNA) is increasingly recognized as a damage-associated molecular pattern (DAMP) that signals mitochondrial injury and the consequent prodeath molecular signature. Such mtDNA release triggers programmed necrotic pathways, specifically necroptosis and pyroptosis, both of which are central to the path...